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Quantifying the regulatory role of individual transcription factors in Escherichia coli

Gene regulation often results from the action of multiple transcription factors (TFs) acting at a promoter, obscuring the individual regulatory effect of each TF on RNA polymerase (RNAP). Here we measure the fundamental regulatory interactions of TFs in E. coli by designing synthetic target genes th...

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Detalles Bibliográficos
Autores principales: Guharajan, Sunil, Chhabra, Shivani, Parisutham, Vinuselvi, Brewster, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667592/
https://www.ncbi.nlm.nih.gov/pubmed/34758318
http://dx.doi.org/10.1016/j.celrep.2021.109952