Missense Mutations Modify the Conformational Ensemble of the α-Synuclein Monomer Which Exhibits a Two-Phase Characteristic

α-Synuclein is an intrinsically disordered protein occurring in different conformations and prone to aggregate in β-sheet structures, which are the hallmark of the Parkinson disease. Missense mutations are associated with familial forms of this neuropathy. How these single amino-acid substitutions m...

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Detalles Bibliográficos
Autores principales: Guzzo, Adrien, Delarue, Patrice, Rojas, Ana, Nicolaï, Adrien, Maisuradze, Gia G., Senet, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667727/
https://www.ncbi.nlm.nih.gov/pubmed/34912851
http://dx.doi.org/10.3389/fmolb.2021.786123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667727/
https://www.ncbi.nlm.nih.gov/pubmed/34912851
http://dx.doi.org/10.3389/fmolb.2021.786123

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