VTT-006, an anti-mitotic compound, binds to the Ndc80 complex and suppresses cancer cell growth in vitro

Hec1 (Highly expressed in cancer 1) resides in the outer kinetochore where it works to facilitate proper kinetochore-microtubule interactions during mitosis. Hec1 is overexpressed in various cancers and its expression shows correlation with high tumour grade and poor patient prognosis. Chemical pert...

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Detalles Bibliográficos
Autores principales: Laine, Leena J., Mäki-Jouppila, Jenni H.E., Kutvonen, Emma, Tiikkainen, Pekka, Nyholm, Thomas K.M., Tien, Jerry F., Umbreit, Neil T., Härmä, Ville, Kallio, Lila, Davis, Trisha N., Asbury, Charles L., Poso, Antti, Gorbsky, Gary J., Kallio, Marko J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667816/
https://www.ncbi.nlm.nih.gov/pubmed/34926718
http://dx.doi.org/10.18632/oncoscience.549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667816/
https://www.ncbi.nlm.nih.gov/pubmed/34926718
http://dx.doi.org/10.18632/oncoscience.549

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