A polypeptide inhibitor of calcineurin blocks the calcineurin-NFAT signalling pathway in vivo and in vitro

Calcineurin (CN) controls the immune response by regulating nuclear factor of activated T cells (NFAT). Inhibition of CN function is an effective treatment for immune diseases. The PVIVIT peptide is an artificial peptide based on the NFAT-PxIxIT motif, which exhibits stronger binding to CN. A bioact...

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Detalles Bibliográficos
Autores principales: Wang, Ping, Li, Wenying, Yang, Yumeng, Cheng, Na, Zhang, Yuchen, Zhang, Nan, Yin, Yanxia, Tong, Li, Li, Zhimei, Luo, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667882/
https://www.ncbi.nlm.nih.gov/pubmed/34894973
http://dx.doi.org/10.1080/14756366.2021.1998024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667882/
https://www.ncbi.nlm.nih.gov/pubmed/34894973
http://dx.doi.org/10.1080/14756366.2021.1998024

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