Cargando…

A polypeptide inhibitor of calcineurin blocks the calcineurin-NFAT signalling pathway in vivo and in vitro

Calcineurin (CN) controls the immune response by regulating nuclear factor of activated T cells (NFAT). Inhibition of CN function is an effective treatment for immune diseases. The PVIVIT peptide is an artificial peptide based on the NFAT-PxIxIT motif, which exhibits stronger binding to CN. A bioact...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Ping, Li, Wenying, Yang, Yumeng, Cheng, Na, Zhang, Yuchen, Zhang, Nan, Yin, Yanxia, Tong, Li, Li, Zhimei, Luo, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667882/ https://www.ncbi.nlm.nih.gov/pubmed/34894973 http://dx.doi.org/10.1080/14756366.2021.1998024

Ejemplares similares

Balanced interactions of calcineurin with AKAP79 regulate Ca(2+)–calcineurin–NFAT signaling
por: Li, Huiming, et al.
Publicado: (2012)

Calcineurin/NFAT signalling inhibits myeloid haematopoiesis
por: Fric, Jan, et al.
Publicado: (2012)

The Role of Calcineurin/NFAT in SFRP2 Induced Angiogenesis—A Rationale for Breast Cancer Treatment with the Calcineurin Inhibitor Tacrolimus
por: Siamakpour-Reihani, Sharareh, et al.
Publicado: (2011)

Nephrotoxicity of Calcineurin Inhibitors in Kidney Epithelial Cells is Independent of NFAT Signaling
por: Karolin, Andrea, et al.
Publicado: (2022)

Astrocyte Activation and the Calcineurin/NFAT Pathway in Cerebrovascular Disease
por: Kraner, Susan D., et al.
Publicado: (2018)

The role of Ca(2+)/Calcineurin/NFAT signalling pathway in osteoblastogenesis
por: Ren, Ranyue, et al.
Publicado: (2021)

Inhibition of Calcineurin/NFAT Signaling Blocks Oncogenic H-Ras Induced Autophagy in Primary Human Keratinocytes
por: Wang, Shuangshuang, et al.
Publicado: (2021)

Calcineurin inhibitors reduce NFAT‐dependent expression of antifungal pentraxin‐3 by human monocytes
por: Bendíčková, Kamila, et al.
Publicado: (2019)

T-Plastin Expression Downstream to the Calcineurin/NFAT Pathway Is Involved in Keratinocyte Migration
por: Brun, Cécilia, et al.
Publicado: (2014)

Micro-RNA Feedback Loops Modulating the Calcineurin/NFAT Signaling Pathway
por: Kannambath, Shichina
Publicado: (2016)

The Role of Calcium–Calcineurin–NFAT Signaling Pathway in Health and Autoimmune Diseases
por: Park, Yune-Jung, et al.
Publicado: (2020)

Immunosuppression Affects Neutrophil Functions: Does Calcineurin-NFAT Signaling Matter?
por: Vymazal, Ondřej, et al.
Publicado: (2021)

Phagocytosis of Particulate Antigens – All Roads Lead to Calcineurin/NFAT Signaling Pathway
por: Fric, Jan, et al.
Publicado: (2014)

Calcineurin–NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy
por: Bendickova, Kamila, et al.
Publicado: (2017)

Delivery of the VIVIT Peptide to Human Glioma Cells to Interfere with Calcineurin-NFAT Signaling
por: Ellert-Miklaszewska, Aleksandra, et al.
Publicado: (2021)

Calcineurin-nuclear factor for activated T cells (NFAT) signaling in pathophysiology of wound healing
por: Manabe, Takahiro, et al.
Publicado: (2021)

Characterization of calcineurin from Cryptococcus humicola and the application of calcineurin in aluminum tolerance
por: Zhang, Lei, et al.
Publicado: (2017)

Calcineurin
por: Creamer, Trevor P.
Publicado: (2020)

Arsenic Trioxide Inhibits the Metastasis of Small Cell Lung Cancer by Blocking Calcineurin-Nuclear Factor of Activated T Cells (NFAT) Signaling
por: Zheng, Jin-Cheng, et al.
Publicado: (2019)

The RCAN1.4-calcineurin/NFAT signaling pathway is essential for hypoxic adaption of intervertebral discs
por: Huang, Bao, et al.
Publicado: (2020)

Prokineticin 1 modulates IL-8 expression via the calcineurin/NFAT signaling pathway
por: Maldonado-Pérez, David, et al.
Publicado: (2009)

Calcineurin/NFAT Activation-Dependence of Leptin Synthesis and Vascular Growth in Response to Mechanical Stretch
por: Soudani, Nadia, et al.
Publicado: (2016)

Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning
por: Weider, Matthias, et al.
Publicado: (2018)

Ca(2+), Astrocyte Activation and Calcineurin/NFAT Signaling in Age-Related Neurodegenerative Diseases
por: Sompol, Pradoldej, et al.
Publicado: (2018)

Gestational diabetes triggers postpartum cardiac hypertrophy via activation of calcineurin/NFAT signaling
por: Verma, Nirmal, et al.
Publicado: (2021)

Calcineurin Inhibitors and COVID-19
por: Hage, René, et al.
Publicado: (2022)

Calcineurin Inhibitors in Membranous Nephropathy
por: Ponticelli, Claudio, et al.
Publicado: (2021)

Calcineurin Inhibitors and COVID-19
por: Hage, René, et al.
Publicado: (2022)

Structure-Based Optimization of a Peptidyl Inhibitor against Calcineurin-Nuclear Factor of Activated T Cell (NFAT) Interaction
por: Qian, Ziqing, et al.
Publicado: (2014)

Cooperative Binding of ETS2 and NFAT Links Erk1/2 and Calcineurin Signaling in the Pathogenesis of Cardiac Hypertrophy
por: Luo, Yuxuan, et al.
Publicado: (2021)

Sanggenon C protects against pressure overload-induced cardiac hypertrophy via the calcineurin/NFAT2 pathway
por: Xiao, Lili, et al.
Publicado: (2017)

Calcineurin and Systemic Lupus Erythematosus: The Rationale for Using Calcineurin Inhibitors in the Treatment of Lupus Nephritis
por: Rafael-Vidal, Carlos, et al.
Publicado: (2021)

TRPV2-induced Ca(2+)-calcineurin-NFAT signaling regulates differentiation of osteoclast in multiple myeloma
por: Bai, Hua, et al.
Publicado: (2018)

Lercanidipine attenuates angiotensin II-induced cardiomyocyte hypertrophy by blocking calcineurin-NFAT3 and CaMKII-HDAC4 signaling
por: Chen, Yuezhang, et al.
Publicado: (2017)

Parathyroid Hormone Induction of Cyclooxygenase-2 in Murine Osteoblasts: Role of the Calcium-Calcineurin-NFAT Pathway
por: Huang, Hechang, et al.
Publicado: (2010)

Resistance to ABT-737 in activated T lymphocytes: molecular mechanisms and reversibility by inhibition of the calcineurin–NFAT pathway
por: Cippà, P E, et al.
Publicado: (2012)

The calcineurin-NFAT pathway controls activity-dependent circadian gene expression in slow skeletal muscle
por: Dyar, Kenneth A., et al.
Publicado: (2015)

Sumoylation-independent activation of Calcineurin-NFAT-signaling via SUMO2 mediates cardiomyocyte hypertrophy
por: Bernt, Alexander, et al.
Publicado: (2016)

Formaldehyde exposure induces regulatory T cell-mediated immunosuppression via calcineurin-NFAT signalling pathway
por: Park, Jeongsik, et al.
Publicado: (2020)

RCAN1.4 suppresses the osteosarcoma growth and metastasis via interfering with the calcineurin/NFAT signaling pathway
por: Huang, Bao, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3e6barkpbmqjat5kdb6sdssqlf