Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer agents: design, synthesis, anti-proliferative, docking, and in vivo studies

This research presents the design and synthesis of a novel series of phthalazine derivatives as Topo II inhibitors, DNA intercalators, and cytotoxic agents. In vitro testing of the new compounds against HepG-2, MCF-7, and HCT-116 cell lines confirmed their potent cytotoxic activity with low IC(50) v...

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Detalles Bibliográficos
Autores principales: Khalifa, Mohamed M., Al-Karmalawy, Ahmed A., Elkaeed, Eslam B., Nafie, Mohamed S., Tantawy, Mohamed A., Eissa, Ibrahim H., Mahdy, Hazem A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667898/
https://www.ncbi.nlm.nih.gov/pubmed/34894955
http://dx.doi.org/10.1080/14756366.2021.2007905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667898/
https://www.ncbi.nlm.nih.gov/pubmed/34894955
http://dx.doi.org/10.1080/14756366.2021.2007905

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