Design, synthesis, and evaluation of chalcone-Vitamin E-donepezil hybrids as multi-target-directed ligands for the treatment of Alzheimer’s disease

A novel series of chalcone-Vitamin E-donepezil hybrids was designed and developed based on multitarget-directed ligands (MTDLs) strategy for treating Alzheimer’s disease (AD). The biological results revealed that compound 17f showed good AChE inhibitory potency (ratAChE IC(50) = 0.41 µM; eeAChE IC(5...

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Detalles Bibliográficos
Autores principales: Sang, Zhipei, Song, Qing, Cao, Zhongcheng, Deng, Yong, Zhang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667902/
https://www.ncbi.nlm.nih.gov/pubmed/34894968
http://dx.doi.org/10.1080/14756366.2021.1993845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667902/
https://www.ncbi.nlm.nih.gov/pubmed/34894968
http://dx.doi.org/10.1080/14756366.2021.1993845

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