Cargando…

Dasatinib ameliorates thioacetamide-induced liver fibrosis: modulation of miR-378 and miR-17 and their linked Wnt/β-catenin and TGF-β/smads pathways

Hepatic stellate cells activation (HSCs) plays a crucial role in the pathogenesis of liver fibrosis. Specific microRNAs have been suggested to affect the activation of HSCs via various signalling pathways including TGF-β/smads and Wnt/β-catenin pathways. Dasatinib is a multitarget inhibitor of many...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zaafan, Mai A., Abdelhamid, Amr M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667920/ https://www.ncbi.nlm.nih.gov/pubmed/34894966 http://dx.doi.org/10.1080/14756366.2021.1995379

Ejemplares similares

The Hepatoprotective Effect of Piperine Against Thioacetamide-Induced Liver Fibrosis in Mice: The Involvement of miR-17 and TGF-β/Smads Pathways
por: Abdelhamid, Amr M., et al.
Publicado: (2021)

miR-378 functions as an onco-miRNA by targeting the ST7L/Wnt/β-catenin pathway in cervical cancer
por: Li, Shengjie, et al.
Publicado: (2017)

TGF-β1 regulating miR-205/miR-195 expression affects the TGF-β signal pathway by respectively targeting SMAD2/SMAD7
por: Duan, Yingjun, et al.
Publicado: (2016)

MiR-378a suppresses tenogenic differentiation and tendon repair by targeting at TGF-β2
por: Liu, Yang, et al.
Publicado: (2019)

TGF-β1/Smads and miR-21 in Renal Fibrosis and Inflammation
por: Loboda, Agnieszka, et al.
Publicado: (2016)

Effect of TGF-β/smad signaling pathway blocking on expression profiles of miR-335, miR-150, miR-194, miR-27a, and miR-199a of hepatic stellate cells (HSCs)
por: Davoodian, Parivash, et al.
Publicado: (2017)

miR-145 is differentially regulated by TGF-β(1) and ischaemia and targets Disabled-2 expression and wnt/β-catenin activity
por: Mayorga, Maritza E, et al.
Publicado: (2012)

NFAT3 and TGF-β/SMAD3 regulate the expression of miR-140 in osteoarthritis
por: Tardif, Ginette, et al.
Publicado: (2013)

Depicting the Implication of miR-378a in Cancers
por: Qin, Yuelan, et al.
Publicado: (2022)

Circulating miR-378 and miR-451 in serum are potential biomarkers for renal cell carcinoma
por: Redova, Martina, et al.
Publicado: (2012)

miR-196b, miR-378a and miR-486 are predictive biomarkers for the efficacy of vaccine treatment in colorectal cancer
por: Shindo, Yoshitaro, et al.
Publicado: (2017)

Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC
por: Cai, Junchao, et al.
Publicado: (2017)

miR-4666-3p and miR-329 Synergistically Suppress the Stemness of Colorectal Cancer Cells via Targeting TGF-β/Smad Pathway
por: Ye, Jun, et al.
Publicado: (2019)

miR-211 alleviates ischaemia/reperfusion-induced kidney injury by targeting TGFβR2/TGF-β/SMAD3 pathway
por: Shang, Jinchun, et al.
Publicado: (2020)

Circulating miR-21, miR-378, and miR-940 increase in response to an acute exhaustive exercise in chronic heart failure patients
por: Xu, Tianzhao, et al.
Publicado: (2016)

lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/β-catenin signaling
por: Lu, Yuanyuan, et al.
Publicado: (2017)

MiR-21/Smad 7 signaling determines TGF-β1-induced CAF formation
por: Li, Qiong, et al.
Publicado: (2013)

Smad2-Dependent Downregulation of miR-30 Is Required for TGF-β-Induced Apoptosis in Podocytes
por: Shi, Shaolin, et al.
Publicado: (2013)

miR-127 accelerates myocardial failure by promoting TGF-β1/Smad3 signaling
por: Xu, Hainian, et al.
Publicado: (2019)

miR-1306 Mediates the Feedback Regulation of the TGF-β/SMAD Signaling Pathway in Granulosa Cells
por: Yang, Liu, et al.
Publicado: (2019)

miR-127 aggravates myocardial failure by promoting the TGF-β1/Smad3 signaling
por: Xu, Hainian, et al.
Publicado: (2018)

Hsa-miR-587 Regulates TGFβ/SMAD Signaling and Promotes Cell Cycle Progression
por: Jahangirimoez, Mahnaz, et al.
Publicado: (2020)

MiR-744 increases tumorigenicity of pancreatic cancer by activating Wnt/β-catenin pathway
por: Zhou, Wei, et al.
Publicado: (2015)

Inhibition of miR-194 suppresses the Wnt/β-catenin signalling pathway in gastric cancer
por: Peng, Yin, et al.
Publicado: (2018)

miR-4721, Induced by EBV-miR-BART22, Targets GSK3β to Enhance the Tumorigenic Capacity of NPC through the WNT/β-catenin Pathway
por: Tang, ZiBo, et al.
Publicado: (2020)

Aberrant Expression of miR-103, miR-184, miR-378, miR-497 and miR-506 in Tumor Tissue from Patients with Oral Squamous Cell Carcinoma Regulates the Clinical Picture of the Patients
por: Ghaffari, Maryam, et al.
Publicado: (2020)

Combination of MiR-378 and MiR-210 Serum Levels Enables Sensitive Detection of Renal Cell Carcinoma
por: Fedorko, Michal, et al.
Publicado: (2015)

Identification of serum miR-378 and miR-575 as diagnostic indicators and predicting surgical prognosis in human epilepsy
por: Li, Xiuxiu, et al.
Publicado: (2022)

The effects of the miR-21/SMAD7/TGF-β pathway on Th17 cell differentiation in COPD
por: He, Shengyang, et al.
Publicado: (2021)

miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation
por: Adusumilli, Lavanya, et al.
Publicado: (2020)

Expression Profiling and Functional Characterization of miR-26a and miR-130a in Regulating Zhongwei Goat Hair Development via the TGF-β/SMAD Pathway
por: Ding, Yangyang, et al.
Publicado: (2020)

Circ_0082182 promotes oncogenesis and metastasis of colorectal cancer in vitro and in vivo by sponging miR-411 and miR-1205 to activate the Wnt/β-catenin pathway
por: Liu, Ruijie, et al.
Publicado: (2021)

Publisher Correction: Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC
por: Cai, Junchao, et al.
Publicado: (2018)

The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology
por: Krist, Bart, et al.
Publicado: (2015)

Lack of miR-378 attenuates muscular dystrophy in mdx mice
por: Podkalicka, Paulina, et al.
Publicado: (2020)

LncRNA-MIR17HG mediated upregulation of miR-17 and miR-18a promotes colon cancer progression via activating Wnt/β-catenin signaling
por: Yuan, Guangwen, et al.
Publicado: (2019)

MiR-208b/miR-21 Promotes the Progression of Cardiac Fibrosis Through the Activation of the TGF-β1/Smad-3 Signaling Pathway: An in vitro and in vivo Study
por: Zhang, Yifan, et al.
Publicado: (2022)

miR-182-5p and miR-378a-3p regulate ferroptosis in I/R-induced renal injury
por: Ding, Chenguang, et al.
Publicado: (2020)

Physical Exercise Modulates miR-21-5p, miR-129-5p, miR-378-5p, and miR-188-5p Expression in Progenitor Cells Promoting Osteogenesis
por: Valenti, Maria Teresa, et al.
Publicado: (2019)

MiR-181b regulates cisplatin chemosensitivity and metastasis by targeting TGFβR1/Smad signaling pathway in NSCLC
por: Wang, Xiaoyuan, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_278ql2fbbqai3p3cf8s505341u