New 1,2,4-oxadiazole derivatives with positive mGlu(4) receptor modulation activity and antipsychotic-like properties

Considering the allosteric regulation of mGlu receptors for potential therapeutic applications, we developed a group of 1,2,4-oxadiazole derivatives that displayed mGlu(4) receptor positive allosteric modulatory activity (EC(50) = 282–656 nM). Selectivity screening revealed that they were devoid of...

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Detalles Bibliográficos
Autores principales: Stankiewicz, Anna, Kaczorowska, Katarzyna, Bugno, Ryszard, Kozioł, Aneta, Paluchowska, Maria H., Burnat, Grzegorz, Chruścicka, Barbara, Chorobik, Paulina, Brański, Piotr, Wierońska, Joanna M., Duszyńska, Beata, Pilc, Andrzej, Bojarski, Andrzej J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667925/
https://www.ncbi.nlm.nih.gov/pubmed/34894953
http://dx.doi.org/10.1080/14756366.2021.1998022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667925/
https://www.ncbi.nlm.nih.gov/pubmed/34894953
http://dx.doi.org/10.1080/14756366.2021.1998022

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