Novel sulphonamide-bearing methoxyquinazolinone derivatives as anticancer and apoptosis inducers: synthesis, biological evaluation and in silico studies

We synthesised a new series of sulphonamide-bearing quinazolinone derivatives 5-18 and evaluated their in vitro cytotoxicity in various cancer cell lines (A549, HepG-2, LoVo and MCF-7) and in normal human cells (HUVEC). Compounds 6 and 10 exhibited the higher activity against all the cancer cell lin...

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Detalles Bibliográficos
Autores principales: Alqahtani, Ali S., Ghorab, Mostafa M., Nasr, Fahd A., Ahmed, Mohammad Z., Al-Mishari, Abdullah A., Attia, Sabry M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667930/
https://www.ncbi.nlm.nih.gov/pubmed/34894963
http://dx.doi.org/10.1080/14756366.2021.1983807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667930/
https://www.ncbi.nlm.nih.gov/pubmed/34894963
http://dx.doi.org/10.1080/14756366.2021.1983807

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