Structure-based virtual screening and biological evaluation of novel small-molecule BTK inhibitors

Bruton tyrosine kinase (BTK) is linked to multiple signalling pathways that regulate cellular survival, activation, and proliferation. A covalent BTK inhibitor has shown favourable outcomes for treating B cell malignant leukaemia. However, covalent inhibitors require a high reactive warhead that may...

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Detalles Bibliográficos
Autores principales: Lin, Tony Eight, Sung, Li-Chin, Chao, Min-Wu, Li, Min, Zheng, Jia-Huei, Sung, Tzu-Ying, Hsieh, Jui-Hua, Yang, Chia-Ron, Lee, Hsueh-Yun, Cho, Er-Chieh, Hsu, Kai-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667945/
https://www.ncbi.nlm.nih.gov/pubmed/34894949
http://dx.doi.org/10.1080/14756366.2021.1999237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667945/
https://www.ncbi.nlm.nih.gov/pubmed/34894949
http://dx.doi.org/10.1080/14756366.2021.1999237

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