Rpl24(Bst) mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K

Increased protein synthesis supports the rapid cell proliferation associated with cancer. The Rpl24(Bst) mutant mouse reduces the expression of the ribosomal protein RPL24 and has been used to suppress translation and limit tumorigenesis in multiple mouse models of cancer. Here, we show that Rpl24(B...

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Detalles Bibliográficos
Autores principales: Knight, John RP, Vlahov, Nikola, Gay, David M, Ridgway, Rachel A, Faller, William James, Proud, Christopher, Mallucci, Giovanna R, von der Haar, Tobias, Smales, Christopher Mark, Willis, Anne E, Sansom, Owen J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668188/
https://www.ncbi.nlm.nih.gov/pubmed/34895463
http://dx.doi.org/10.7554/eLife.69729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668188/
https://www.ncbi.nlm.nih.gov/pubmed/34895463
http://dx.doi.org/10.7554/eLife.69729

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