Cargando…

Rpl24(Bst) mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K

Increased protein synthesis supports the rapid cell proliferation associated with cancer. The Rpl24(Bst) mutant mouse reduces the expression of the ribosomal protein RPL24 and has been used to suppress translation and limit tumorigenesis in multiple mouse models of cancer. Here, we show that Rpl24(B...

Descripción completa

Detalles Bibliográficos
Autores principales:	Knight, John RP, Vlahov, Nikola, Gay, David M, Ridgway, Rachel A, Faller, William James, Proud, Christopher, Mallucci, Giovanna R, von der Haar, Tobias, Smales, Christopher Mark, Willis, Anne E, Sansom, Owen J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668188/ https://www.ncbi.nlm.nih.gov/pubmed/34895463 http://dx.doi.org/10.7554/eLife.69729

Ejemplares similares

Eukaryotic Elongation Factor 2 Kinase (eEF2K) in Cancer
por: Wang, Xuemin, et al.
Publicado: (2017)

Ribosomal stress activates eEF2K–eEF2 pathway causing translation elongation inhibition and recruitment of Terminal Oligopyrimidine (TOP) mRNAs on polysomes
por: Gismondi, Angelo, et al.
Publicado: (2014)

Novel regulation of the eEF2K/eEF2 pathway: prospects of ‘PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation’
por: Shen, Yuqian, et al.
Publicado: (2021)

Coordination of changes in expression and phosphorylation of eukaryotic elongation factor 2 (eEF2) and eEF2 kinase in hypertrophied cardiomyocytes
por: Kameshima, Satoshi, et al.
Publicado: (2016)

Eukaryotic Elongation Factor 2 Kinase Activity Is Required for the Phenotypes of the Rpl24(Bst) Mouse
por: Knight, John R.P., et al.
Publicado: (2022)

On the Need to Tell Apart Fraternal Twins eEF1A1 and eEF1A2, and Their Respective Outfits
por: Mills, Alberto, et al.
Publicado: (2021)

Analysis of the Expression and Subcellular Distribution of eEF1A1 and eEF1A2 mRNAs during Neurodevelopment
por: Wefers, Zoe, et al.
Publicado: (2022)

SIRT1 Protects the Heart from ER Stress-Induced Injury by Promoting eEF2K/eEF2-Dependent Autophagy
por: Pires Da Silva, Julie, et al.
Publicado: (2020)

Ghrelin rapidly elevates protein synthesis in vitro by employing the rpS6K-eEF2K-eEF2 signalling axis
por: Zhdanov, Alexander V., et al.
Publicado: (2022)

Electroacupuncture Improves Synaptic Function in SAMP8 Mice Probably via Inhibition of the AMPK/eEF2K/eEF2 Signaling Pathway
por: Dong, Weiguo, et al.
Publicado: (2019)

A functional eEF2K-eEF2 pathway in the NAc is critical for the expression of cocaine-induced psychomotor sensitisation and conditioned place preference
por: Beiser, Tehila, et al.
Publicado: (2022)

Characterisation of Translation Elongation Factor eEF1B Subunit Expression in Mammalian Cells and Tissues and Co-Localisation with eEF1A2
por: Cao, Yuan, et al.
Publicado: (2014)

High eEF1A1 Protein Levels Mark Aggressive Prostate Cancers and the In Vitro Targeting of eEF1A1 Reveals the eEF1A1–actin Complex as a New Potential Target for Therapy
por: Bosutti, Alessandra, et al.
Publicado: (2022)

Ribosome profiling analysis of eEF3-depleted Saccharomyces cerevisiae
por: Kasari, Villu, et al.
Publicado: (2019)

Structural Models of Human eEF1A1 and eEF1A2 Reveal Two Distinct Surface Clusters of Sequence Variation and Potential Differences in Phosphorylation
por: Soares, Dinesh C., et al.
Publicado: (2009)

Dimethylation of eEF1A at Lysine 55 Plays a Key Role in the Regulation of eEF1A2 on Malignant Cell Functions of Acute Myeloid Leukemia
por: Xiao, Shan, et al.
Publicado: (2020)

Highly homologous eEF1A1 and eEF1A2 exhibit differential post-translational modification with significant enrichment around localised sites of sequence variation
por: Soares, Dinesh C, et al.
Publicado: (2013)

The alphavirus nonstructural protein 2 NTPase induces a host translational shut-off through phosphorylation of eEF2 via cAMP-PKA-eEF2K signaling
por: Treffers, Emmely E., et al.
Publicado: (2023)

Evidence for a Negative Cooperativity between eIF5A and eEF2 on Binding to the Ribosome
por: Rossi, Danuza, et al.
Publicado: (2016)

The eEF1A Proteins: At the Crossroads of Oncogenesis, Apoptosis, and Viral Infections
por: Abbas, Wasim, et al.
Publicado: (2015)

Post-Training Dephosphorylation of eEF-2 Promotes Protein Synthesis for Memory Consolidation
por: Im, Heh-In, et al.
Publicado: (2009)

The role of protein elongation factor eEF1A2 in ovarian cancer
por: Lee, Jonathan M
Publicado: (2003)

The eEF2 kinase-induced STAT3 inactivation inhibits lung cancer cell proliferation by phosphorylation of PKM2
por: Xiao, Min, et al.
Publicado: (2020)

eEF1A Is an S-RNase Binding Factor in Self-Incompatible Solanum chacoense
por: Soulard, Jonathan, et al.
Publicado: (2014)

Non-translational Connections of eEF1B in the Cytoplasm and Nucleus of Cancer Cells
por: Negrutskii, Boris
Publicado: (2020)

Analysis of eEF1A2 gene expression and copy number in cervical carcinoma
por: Zheng, Weinan, et al.
Publicado: (2023)

eEF2K Inhibitor Design: The Progression of Exemplary Structure-Based Drug Design
por: Klupt, Kody A., et al.
Publicado: (2023)

A conserved PUF/Ago/eEF1A complex attenuates translation elongation
por: Friend, Kyle, et al.
Publicado: (2012)

Ethanolamine phosphoglycerol attachment to eEF1A is not essential for normal growth of Trypanosoma brucei
por: Greganova, Eva, et al.
Publicado: (2012)

MLIF Modulates Microglia Polarization in Ischemic Stroke by Targeting eEF1A1
por: Liu, Yulan, et al.
Publicado: (2021)

Novel activity of eukaryotic translocase, eEF2: dissociation of the 80S ribosome into subunits with ATP but not with GTP
por: Demeshkina, Natalia, et al.
Publicado: (2007)

Novel activity of eukaryotic translocase, eEF2: dissociation of the 80S ribosome into subunits with ATP but not with GTP
por: Demeshkina, Natalia, et al.
Publicado: (2007)

AMPK activation, eEF2 inactivation, and reduced protein synthesis in the cerebral cortex of hibernating chipmunks
por: Yamada, Shintaro, et al.
Publicado: (2019)

Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance
por: Smith, Patrick R., et al.
Publicado: (2021)

Sordarin bound eEF2 unlocks spontaneous forward and reverse translocation on CrPV IRES
por: Ou, Zheren, et al.
Publicado: (2023)

Expression of eEF1A2 is associated with clear cell histology in ovarian carcinomas: overexpression of the gene is not dependent on modifications at the EEF1A2 locus
por: Tomlinson, V A L, et al.
Publicado: (2007)

Isolation of Flavonoids from Deguelia duckeana and Their Effect on Cellular Viability, AMPK, eEF2, eIF2 and eIF4E
por: Cursino, Lorena M. C., et al.
Publicado: (2016)

The eEF1γ Subunit Contacts RNA Polymerase II and Binds Vimentin Promoter Region
por: Corbi, Nicoletta, et al.
Publicado: (2010)

eEF1Bγ binds the Che-1 and TP53 gene promoters and their transcripts
por: Pisani, Cinzia, et al.
Publicado: (2016)

Collaboration of tRNA modifications and elongation factor eEF1A in decoding and nonsense suppression
por: Klassen, Roland, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_9qnue6ehh6pg45hqgg2h0ta19h