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Effect of early treatment with metformin on risk of emergency care and hospitalization among patients with COVID-19: The TOGETHER randomized platform clinical trial

BACKGROUND: Observational studies have postulated a therapeutic role of metformin in treating COVID-19. We conducted an adaptive platform clinical trial to determine whether metformin is an effective treatment for high-risk patients with early COVID-19 in an outpatient setting. METHODS: The TOGETHER...

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Detalles Bibliográficos
Autores principales: Reis, Gilmar, dos Santos Moreira Silva, Eduardo Augusto, Medeiros Silva, Daniela Carla, Thabane, Lehana, Cruz Milagres, Aline, Ferreira, Thiago Santiago, Quirino dos Santos, Castilho Vitor, de Figueiredo Neto, Adhemar Dias, Diniz Callegari, Eduardo, Monteiro Savassi, Leonardo Cançado, Campos Simplicio, Maria Izabel, Barra Ribeiro, Luciene, Oliveira, Rosemary, Harari, Ofir, Bailey, Holly, Forrest, Jamie I, Glushchenko, Alla, Sprague, Sheila, McKay, Paula, Rayner, Craig R., Ruton, Hinda, Guyatt, Gordon H., Mills, Edward J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668402/
https://www.ncbi.nlm.nih.gov/pubmed/34927127
http://dx.doi.org/10.1016/j.lana.2021.100142