Non-canonical function of FIP200 is required for neural stem cell maintenance and differentiation by limiting TBK1 activation and p62 aggregate formation

FIP200 is an essential autophagy gene implicated in the regulation of postnatal neural progenitor/stem cells (NSCs). However, the contribution of FIP200’s canonical-autophagy function and its non-canonical functions to postnatal NSC maintenance remains unclear. Utilizing a recently generated Fip200-...

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Detalles Bibliográficos
Autores principales: Liu, Hang, Wang, Chenran, Yi, Fei, Yeo, Syn, Haas, Michael, Tang, Xin, Guan, Jun-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668875/
https://www.ncbi.nlm.nih.gov/pubmed/34903812
http://dx.doi.org/10.1038/s41598-021-03404-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668875/
https://www.ncbi.nlm.nih.gov/pubmed/34903812
http://dx.doi.org/10.1038/s41598-021-03404-7

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