CRISPR/Cas9-mediated base-editing enables a chain reaction through sequential repair of sgRNA scaffold mutations

Cell behavior is controlled by complex gene regulatory networks. Although studies have uncovered diverse roles of individual genes, it has been challenging to record or control sequential genetic events in living cells. In this study, we designed two cellular chain reaction systems that enable seque...

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Detalles Bibliográficos
Autores principales: Fukushima, Tsuyoshi, Tanaka, Yosuke, Adachi, Keito, Masuyama, Nanami, Tsuchiya, Akiho, Asada, Shuhei, Ishiguro, Soh, Mori, Hideto, Seki, Motoaki, Yachie, Nozomu, Goyama, Susumu, Kitamura, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668876/
https://www.ncbi.nlm.nih.gov/pubmed/34903756
http://dx.doi.org/10.1038/s41598-021-02986-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668876/
https://www.ncbi.nlm.nih.gov/pubmed/34903756
http://dx.doi.org/10.1038/s41598-021-02986-6

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