Cell-specific alterations in Pitx1 regulatory landscape activation caused by the loss of a single enhancer

Developmental genes are frequently controlled by multiple enhancers sharing similar specificities. As a result, deletions of such regulatory elements have often failed to reveal their full function. Here, we use the Pitx1 testbed locus to characterize in detail the regulatory and cellular identity a...

Descripción completa

Detalles Bibliográficos
Autores principales: Rouco, Raquel, Bompadre, Olimpia, Rauseo, Antonella, Fazio, Olivier, Peraldi, Rodrigue, Thorel, Fabrizio, Andrey, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668926/
https://www.ncbi.nlm.nih.gov/pubmed/34903763
http://dx.doi.org/10.1038/s41467-021-27492-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668926/
https://www.ncbi.nlm.nih.gov/pubmed/34903763
http://dx.doi.org/10.1038/s41467-021-27492-1

Ejemplares similares