Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain

Dipeptidyl peptidase-4 (DPP4) plays a crucial role in regulating the bioactivity of glucagon-like peptide-1 (GLP-1) that enhances insulin secretion and pancreatic β-cell proliferation, making it a therapeutic target for type 2 diabetes. Although the crystal structure of DPP4 has been determined, its...

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Detalles Bibliográficos
Autores principales: Li, Teng-teng, Peng, Cheng, Wang, Ji-qiu, Xu, Zhi-jian, Su, Ming-bo, Li, Jia, Zhu, Wei-liang, Li, Jing-ya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669218/
https://www.ncbi.nlm.nih.gov/pubmed/34907358
http://dx.doi.org/10.1038/s41401-021-00818-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669218/
https://www.ncbi.nlm.nih.gov/pubmed/34907358
http://dx.doi.org/10.1038/s41401-021-00818-x

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