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Cryo-EM structure of MukBEF reveals DNA loop entrapment at chromosomal unloading sites

The ring-like structural maintenance of chromosomes (SMC) complex MukBEF folds the genome of Escherichia coli and related bacteria into large loops, presumably by active DNA loop extrusion. MukBEF activity within the replication terminus macrodomain is suppressed by the sequence-specific unloader Ma...

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Detalles Bibliográficos
Autores principales: Bürmann, Frank, Funke, Louise F.H., Chin, Jason W., Löwe, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669397/
https://www.ncbi.nlm.nih.gov/pubmed/34739874
http://dx.doi.org/10.1016/j.molcel.2021.10.011