Increased B Cell Selection Stringency In Germinal Centers Can Explain Improved COVID-19 Vaccine Efficacies With Low Dose Prime or Delayed Boost

The efficacy of COVID-19 vaccines appears to depend in complex ways on the vaccine dosage and the interval between the prime and boost doses. Unexpectedly, lower dose prime and longer prime-boost intervals have yielded higher efficacies in clinical trials. To elucidate the origins of these effects,...

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Detalles Bibliográficos
Autores principales: Garg, Amar K., Mittal, Soumya, Padmanabhan, Pranesh, Desikan, Rajat, Dixit, Narendra M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669483/
https://www.ncbi.nlm.nih.gov/pubmed/34917089
http://dx.doi.org/10.3389/fimmu.2021.776933

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669483/
https://www.ncbi.nlm.nih.gov/pubmed/34917089
http://dx.doi.org/10.3389/fimmu.2021.776933

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