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Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas

OBJECTIVE: Sulfonylureas, the first available drugs for the management of type 2 diabetes, remain widely prescribed today. However, there exists significant variability in glycemic response to treatment. We aimed to establish heritability of sulfonylurea response and identify genetic variants and in...

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Detalles Bibliográficos
Autores principales: Dawed, Adem Y., Yee, Sook Wah, Zhou, Kaixin, van Leeuwen, Nienke, Zhang, Yanfei, Siddiqui, Moneeza K., Etheridge, Amy, Innocenti, Federico, Xu, Fei, Li, Josephine H., Beulens, Joline W., van der Heijden, Amber A., Slieker, Roderick C., Chang, Yu-Chuan, Mercader, Josep M., Kaur, Varinderpal, Witte, John S., Lee, Ming Ta Michael, Kamatani, Yoichiro, Momozawa, Yukihide, Kubo, Michiaki, Palmer, Colin N.A., Florez, Jose C., Hedderson, Monique M., ‘t Hart, Leen M., Giacomini, Kathleen M., Pearson, Ewan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669535/
https://www.ncbi.nlm.nih.gov/pubmed/34607834
http://dx.doi.org/10.2337/dc21-1152