Allosteric Modulation of NMDARs Reverses Patients' Autoantibody Effects in Mice

BACKGROUND AND OBJECTIVES: To demonstrate that an analog (SGE-301) of a brain-derived cholesterol metabolite, 24(S)-hydroxycholesterol, which is a selective positive allosteric modulator (PAM) of NMDA receptors (NMDARs), is able to reverse the memory and synaptic alterations caused by CSF from patie...

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Detalles Bibliográficos
Autores principales: Radosevic, Marija, Planagumà, Jesús, Mannara, Francesco, Mellado, Araceli, Aguilar, Esther, Sabater, Lidia, Landa, Jon, García-Serra, Anna, Maudes, Estibaliz, Gasull, Xavier, Lewis, Mike, Dalmau, Josep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669659/
https://www.ncbi.nlm.nih.gov/pubmed/34903638
http://dx.doi.org/10.1212/NXI.0000000000001122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669659/
https://www.ncbi.nlm.nih.gov/pubmed/34903638
http://dx.doi.org/10.1212/NXI.0000000000001122

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