Endothelial Dysfunction in Fabry Disease Is Related to Glycocalyx Degradation

Fabry disease (FD) is an X-linked multisystemic lysosomal storage disease due to a deficiency of α-galactosidase A (GLA/AGAL). Progressive cellular accumulation of the AGAL substrate globotriaosylceramide (Gb(3)) leads to endothelial dysfunction. Here, we analyzed endothelial function in vivo and in...

Descripción completa

Detalles Bibliográficos
Autores principales: Pollmann, Solvey, Scharnetzki, David, Manikowski, Dominique, Lenders, Malte, Brand, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670230/
https://www.ncbi.nlm.nih.gov/pubmed/34917096
http://dx.doi.org/10.3389/fimmu.2021.789142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670230/
https://www.ncbi.nlm.nih.gov/pubmed/34917096
http://dx.doi.org/10.3389/fimmu.2021.789142

Ejemplares similares