Pharmacological perturbation reveals deficits in D2 receptor responses in Thap1 null mice

The primary dystonia DYT6 is caused by mutations in the transcription factor Thanatos‐associated protein 1 (THAP1). To understand THAP1’s functions, we generated mice lacking THAP1 in the nervous system. THAP1 loss causes locomotor deficits associated with transcriptional changes. Since many of the...

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Detalles Bibliográficos
Autores principales: Frederick, Natalie M., Pooler, Morgan M., Shah, Parth, Didonna, Alessandro, Opal, Puneet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670318/
https://www.ncbi.nlm.nih.gov/pubmed/34802187
http://dx.doi.org/10.1002/acn3.51481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670318/
https://www.ncbi.nlm.nih.gov/pubmed/34802187
http://dx.doi.org/10.1002/acn3.51481

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