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Inhibition of human lung cancer cells by anti-p21Ras scFv mediated by the activatable cell-penetrating peptide

Activatable cell-penetrating peptide (ACPP) is a tumour-targeting cell-penetrating peptide. Here, we used ACPP to carry anti-p21Ras scFv for Ras-driven cancer therapy. The ACPP-p21Ras scFv fusion protein was prepared by a prokaryotic expression system and Ni-NTA column purification. The human tumour...

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Detalles Bibliográficos
Autores principales: Du, Yu, Lin, Xinrui, Feng, Qiang, Pan, Xinyan, Song, Shuling, Yang, Julun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670359/
https://www.ncbi.nlm.nih.gov/pubmed/34338241
http://dx.doi.org/10.1097/CAD.0000000000001180