Identification and characterization of an atypical Gαs-biased β(2)AR agonist that fails to evoke airway smooth muscle cell tachyphylaxis

G protein–coupled receptors display multifunctional signaling, offering the potential for agonist structures to promote conformational selectivity for biased outputs. For β(2)-adrenergic receptors (β(2)AR), unbiased agonists stabilize conformation(s) that evoke coupling to Gαs (cyclic adenosine mono...

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Detalles Bibliográficos
Autores principales: Kim, Donghwa, Tokmakova, Alina, Lujan, Lauren K., Strzelinski, Hannah R., Kim, Nicholas, Najari Beidokhti, Maliheh, Giulianotti, Marc A., Mafi, Amirhossein, Woo, Jung-A A., An, Steven S., Goddard, William A., Liggett, Stephen B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670521/
https://www.ncbi.nlm.nih.gov/pubmed/34857633
http://dx.doi.org/10.1073/pnas.2026668118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670521/
https://www.ncbi.nlm.nih.gov/pubmed/34857633
http://dx.doi.org/10.1073/pnas.2026668118

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