Molecular modelling and de novo fragment-based design of potential inhibitors of beta-tubulin gene of Necator americanus from natural products

The emergence of drug resistance against the known hookworm drugs namely albendazole and mebendazole and their reduced efficacies necessitate the need for new drugs. Chemically diverse natural products present plausible templates to augment hookworm drug discovery. The present work utilized pharmaco...

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Detalles Bibliográficos
Autores principales: Agyapong, Odame, Asiedu, Seth O., Kwofie, Samuel K., Miller, Whelton A., Parry, Christian S., Sowah, Robert A., Wilson, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670734/
https://www.ncbi.nlm.nih.gov/pubmed/34912942
http://dx.doi.org/10.1016/j.imu.2021.100734

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670734/
https://www.ncbi.nlm.nih.gov/pubmed/34912942
http://dx.doi.org/10.1016/j.imu.2021.100734

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