Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2

Cell cycle gene expression programs fuel proliferation and are universally dysregulated in cancer. The retinoblastoma (RB)-family of proteins, RB1, RBL1/p107, and RBL2/p130, coordinately represses cell cycle gene expression, inhibiting proliferation, and suppressing tumorigenesis. Phosphorylation of...

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Detalles Bibliográficos
Autores principales: Enrico, Taylor P, Stallaert, Wayne, Wick, Elizaveta T, Ngoi, Peter, Wang, Xianxi, Rubin, Seth M, Brown, Nicholas G, Purvis, Jeremy E, Emanuele, Michael J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670743/
https://www.ncbi.nlm.nih.gov/pubmed/34851822
http://dx.doi.org/10.7554/eLife.70691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670743/
https://www.ncbi.nlm.nih.gov/pubmed/34851822
http://dx.doi.org/10.7554/eLife.70691

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