Unexplored Excipients in Biotherapeutic Formulations: Natural Osmolytes as Potential Stabilizers Against Thermally Induced Aggregation of IgG1 Biotherapeutics

Monoclonal antibodies (mAbs), while incredibly successful, are prone to a variety of degradation pathways, the most significant of which is aggregation. One of the most commonly used strategy to overcome protein aggregation is addition of excipients to the formulation. Osmolytes such as trehalose, s...

Descripción completa

Detalles Bibliográficos
Autores principales: Bhojane, Purva P., Joshi, Srishti, Sahoo, Sushree Jagriti, Rathore, Anurag S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670780/
https://www.ncbi.nlm.nih.gov/pubmed/34907498
http://dx.doi.org/10.1208/s12249-021-02183-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670780/
https://www.ncbi.nlm.nih.gov/pubmed/34907498
http://dx.doi.org/10.1208/s12249-021-02183-8

Ejemplares similares