Comparative transcriptome analysis and CRISPR/Cas9 gene editing reveal that E4BP4 mediates lithium upregulation of Per2 expression

Bipolar disorder (BPD) is a psychiatric disorder characterized by alternate episodes of mania and depression. Disruption of normal circadian clock and abnormal sleep cycles are common symptoms of BPD patients. Lithium salt is currently an effective clinical therapeutic drug for BPD. Animal and cellu...

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Detalles Bibliográficos
Autores principales: Zhou, Qin, Wang, Kankan, Qiu, Jiameng, Zhu, Di, Tian, Tian, Zhang, Yunfei, Qin, Ximing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670960/
https://www.ncbi.nlm.nih.gov/pubmed/34905700
http://dx.doi.org/10.1098/rsob.210140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8670960/
https://www.ncbi.nlm.nih.gov/pubmed/34905700
http://dx.doi.org/10.1098/rsob.210140

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