TRAP1 inhibits MIC60 ubiquitination to mitigate the injury of cardiomyocytes and protect mitochondria in extracellular acidosis

Extracellular acidosis-induced mitochondrial damage of cardiomyocytes leads to cardiac dysfunction, but no detailed mechanism or efficient therapeutic target has been reported. Here we found that the protein levels of MIC60 were decreased in H9C2 cells and heart tissues in extracellular acidosis, wh...

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Detalles Bibliográficos
Autores principales: Zhang, Lingxiao, Su, Ning, Luo, Yuanyuan, Chen, Siyin, Zhao, Tongfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671480/
https://www.ncbi.nlm.nih.gov/pubmed/34907169
http://dx.doi.org/10.1038/s41420-021-00786-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671480/
https://www.ncbi.nlm.nih.gov/pubmed/34907169
http://dx.doi.org/10.1038/s41420-021-00786-5

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