Modulation of oxidative and nitrosative stress attenuates microvascular hyperpermeability in ovine model of Pseudomonas aeruginosa sepsis

In sepsis, microvascular hyperpermeability caused by oxidative/nitrosative stress (O&NS) plays an important role in tissue edema leading to multi-organ dysfunctions and increased mortality. We hypothesized that a novel compound R-107, a modulator of O&NS, effectively ameliorates the severity...

Descripción completa

Detalles Bibliográficos
Autores principales: Fukuda, Satoshi, Niimi, Yosuke, Hirasawa, Yasutaka, Manyeza, Ennert R., Garner, C. Edwin, Southan, Garry, Salzman, Andrew L., Prough, Donald S., Enkhbaatar, Perenlei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671546/
https://www.ncbi.nlm.nih.gov/pubmed/34907252
http://dx.doi.org/10.1038/s41598-021-03320-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671546/
https://www.ncbi.nlm.nih.gov/pubmed/34907252
http://dx.doi.org/10.1038/s41598-021-03320-w

Ejemplares similares