Cargando…
Single cell analysis of spondyloarthritis regulatory T cells identifies distinct synovial gene expression patterns and clonal fates
Regulatory T cells (Tregs) play an important role in controlling inflammation and limiting autoimmunity, but their phenotypes at inflammatory sites in human disease are poorly understood. We here analyze the single-cell transcriptome of >16,000 Tregs obtained from peripheral blood and synovial fl...
Autores principales: | Simone, Davide, Penkava, Frank, Ridley, Anna, Sansom, Stephen, Al-Mossawi, M. Hussein, Bowness, Paul |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671562/ https://www.ncbi.nlm.nih.gov/pubmed/34907325 http://dx.doi.org/10.1038/s42003-021-02931-3 |
Ejemplares similares
-
Novel Therapeutic Targets in Axial Spondyloarthritis
por: Worth, Claudia, et al.
Publicado: (2018) -
Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis
por: Penkava, Frank, et al.
Publicado: (2020) -
Activation‐Induced Killer Cell Immunoglobulin‐like Receptor 3DL2 Binding to HLA–B27 Licenses Pathogenic T Cell Differentiation in Spondyloarthritis
por: Ridley, Anna, et al.
Publicado: (2016) -
Progress in our understanding of the pathogenesis of ankylosing spondylitis
por: Simone, Davide, et al.
Publicado: (2018) -
Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis
por: Al-Mossawi, M. H., et al.
Publicado: (2017)