Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson’s Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment

BACKGROUND: Neuroinflammation and mitochondrial impairment play important roles in the neuropathogenesis of Parkinson’s disease (PD). The activation of NLRP3 inflammasome and the accumulation of α-synuclein (α-Syn) are strictly correlated to neuroinflammation. Therefore, the regulation of NLRP3 infl...

Descripción completa

Detalles Bibliográficos
Autores principales: Que, Rongfang, Zheng, Jialing, Chang, Zihan, Zhang, Wenjie, Li, Hualing, Xie, Zhenchao, Huang, Zifeng, Wang, Hai-Tao, Xu, Jiangping, Jin, Dana, Yang, Wanlin, Tan, Eng-King, Wang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671881/
https://www.ncbi.nlm.nih.gov/pubmed/34925379
http://dx.doi.org/10.3389/fimmu.2021.794770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671881/
https://www.ncbi.nlm.nih.gov/pubmed/34925379
http://dx.doi.org/10.3389/fimmu.2021.794770

Ejemplares similares