Population-based study of the association between asthma and exogenous female sex hormone use

OBJECTIVES: Several studies have suggested the influence of exogenous hormones on asthma, but the results are still conflicting. Moreover, there has been little associated research on Asian population. This study aimed to assess the association between use of exogenous female sex hormones and asthma...

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Autores principales: Jung, Won Jai, Lee, Sang Yeub, Choi, Sue In, Kim, Byung-Keun, Lee, Eun Joo, Choi, Jimi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671913/
https://www.ncbi.nlm.nih.gov/pubmed/34903532
http://dx.doi.org/10.1136/bmjopen-2020-046400
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author Jung, Won Jai
Lee, Sang Yeub
Choi, Sue In
Kim, Byung-Keun
Lee, Eun Joo
Choi, Jimi
author_facet Jung, Won Jai
Lee, Sang Yeub
Choi, Sue In
Kim, Byung-Keun
Lee, Eun Joo
Choi, Jimi
author_sort Jung, Won Jai
collection PubMed
description OBJECTIVES: Several studies have suggested the influence of exogenous hormones on asthma, but the results are still conflicting. Moreover, there has been little associated research on Asian population. This study aimed to assess the association between use of exogenous female sex hormones and asthma in Korean women. DESIGN: Korea National Health and Nutrition Examination Survey (KNHANES) is a nationwide programme to assess national health and nutritional status in Korea. A population-based study was conducted to analyse the relationship between self-reported asthma and exogenous hormones using the KNHANES between 2007 and 2012. PARTICIPANTS: The study sample included 6874 premenopausal and 4912 postmenopausal women aged 30–65. OUTCOME MEASURES: KNHANES data comprised health interviews and physical examinations. Questionnaires regarding asthma, reproductive factors and exogenous hormones were included. RESULTS: Among postmenopausal women, 3.4% reported doctor-diagnosed asthma. Hormone replacement therapy (HRT) was associated with increased odds of doctor-diagnosed asthma (OR 1.56; 95% CI 1.04 to 2.35), while the association between HRT and wheeze in the last 1 year was not significant (OR 1.37; 95% CI 0.95 to 1.96). In premenopausal women, the prevalence of asthma was 2.3%. Use of oral contraceptives (OCs) was associated with an increased odds of doctor-diagnosed asthma (OR 1.67; 95% CI 1.01 to 2.76) and wheeze in the last 1 year (OR 1.88; 95% CI 1.31 to 2.69). These associations were dominant among non-obese women (body mass index <25 kg/m(2); OR 2.36; 95% CI 1.34 to 4.17 for asthma and OR 2.15; 95% CI 1.43 to 3.23 for wheeze). CONCLUSIONS: HRT and OCs were associated with increased asthma in postmenopausal and premenopausal women, respectively. The association between OC use and asthma was strong in non-obese premenopausal women.
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spelling pubmed-86719132021-12-28 Population-based study of the association between asthma and exogenous female sex hormone use Jung, Won Jai Lee, Sang Yeub Choi, Sue In Kim, Byung-Keun Lee, Eun Joo Choi, Jimi BMJ Open Respiratory Medicine OBJECTIVES: Several studies have suggested the influence of exogenous hormones on asthma, but the results are still conflicting. Moreover, there has been little associated research on Asian population. This study aimed to assess the association between use of exogenous female sex hormones and asthma in Korean women. DESIGN: Korea National Health and Nutrition Examination Survey (KNHANES) is a nationwide programme to assess national health and nutritional status in Korea. A population-based study was conducted to analyse the relationship between self-reported asthma and exogenous hormones using the KNHANES between 2007 and 2012. PARTICIPANTS: The study sample included 6874 premenopausal and 4912 postmenopausal women aged 30–65. OUTCOME MEASURES: KNHANES data comprised health interviews and physical examinations. Questionnaires regarding asthma, reproductive factors and exogenous hormones were included. RESULTS: Among postmenopausal women, 3.4% reported doctor-diagnosed asthma. Hormone replacement therapy (HRT) was associated with increased odds of doctor-diagnosed asthma (OR 1.56; 95% CI 1.04 to 2.35), while the association between HRT and wheeze in the last 1 year was not significant (OR 1.37; 95% CI 0.95 to 1.96). In premenopausal women, the prevalence of asthma was 2.3%. Use of oral contraceptives (OCs) was associated with an increased odds of doctor-diagnosed asthma (OR 1.67; 95% CI 1.01 to 2.76) and wheeze in the last 1 year (OR 1.88; 95% CI 1.31 to 2.69). These associations were dominant among non-obese women (body mass index <25 kg/m(2); OR 2.36; 95% CI 1.34 to 4.17 for asthma and OR 2.15; 95% CI 1.43 to 3.23 for wheeze). CONCLUSIONS: HRT and OCs were associated with increased asthma in postmenopausal and premenopausal women, respectively. The association between OC use and asthma was strong in non-obese premenopausal women. BMJ Publishing Group 2021-12-13 /pmc/articles/PMC8671913/ /pubmed/34903532 http://dx.doi.org/10.1136/bmjopen-2020-046400 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Respiratory Medicine
Jung, Won Jai
Lee, Sang Yeub
Choi, Sue In
Kim, Byung-Keun
Lee, Eun Joo
Choi, Jimi
Population-based study of the association between asthma and exogenous female sex hormone use
title Population-based study of the association between asthma and exogenous female sex hormone use
title_full Population-based study of the association between asthma and exogenous female sex hormone use
title_fullStr Population-based study of the association between asthma and exogenous female sex hormone use
title_full_unstemmed Population-based study of the association between asthma and exogenous female sex hormone use
title_short Population-based study of the association between asthma and exogenous female sex hormone use
title_sort population-based study of the association between asthma and exogenous female sex hormone use
topic Respiratory Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671913/
https://www.ncbi.nlm.nih.gov/pubmed/34903532
http://dx.doi.org/10.1136/bmjopen-2020-046400
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