Dendrimer-2PMPA selectively blocks upregulated microglial GCPII activity and improves cognition in a mouse model of multiple sclerosis

Cognitive impairment is a common aspect of multiple sclerosis (MS) for which there are no treatments. Reduced brain N-acetylaspartylglutamate (NAAG) levels are linked to impaired cognition in various neurological diseases, including MS. NAAG levels are regulated by glutamate carboxypeptidase II (GCP...

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Detalles Bibliográficos
Autores principales: Hollinger, Kristen R., Sharma, Anjali, Tallon, Carolyn, Lovell, Lyndah, Thomas, Ajit G., Zhu, Xiaolei, Wiseman, Robyn, Wu, Ying, Kambhampati, Siva P., Liaw, Kevin, Sharma, Rishi, Rojas, Camilo, Rais, Rana, Kannan, Sujatha, Kannan, Rangaramanujam M., Slusher, Barbara S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671953/
https://www.ncbi.nlm.nih.gov/pubmed/34976589
http://dx.doi.org/10.7150/ntno.63158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671953/
https://www.ncbi.nlm.nih.gov/pubmed/34976589
http://dx.doi.org/10.7150/ntno.63158

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