The Human SCN10A(G1662S) Point Mutation Established in Mice Impacts on Mechanical, Heat, and Cool Sensitivity

The voltage-gated sodium channel NAV1.8 is expressed in primary nociceptive neurons and is involved in pain transmission. Mutations in the SCN10A gene (encoding NAV1.8 channel) have been identified in patients with idiopathic painful small fiber neuropathy (SFN) including the SCN10A(G1662S) gain-of-...

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Detalles Bibliográficos
Autores principales: Chidiac, Celeste, Xue, Yaping, Muniz Moreno, Maria del Mar, Bakr Rasheed, Ameer Abu, Lorentz, Romain, Birling, Marie-Christine, Gaveriaux-Ruff, Claire, Herault, Yann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671994/
https://www.ncbi.nlm.nih.gov/pubmed/34925037
http://dx.doi.org/10.3389/fphar.2021.780132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671994/
https://www.ncbi.nlm.nih.gov/pubmed/34925037
http://dx.doi.org/10.3389/fphar.2021.780132

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