Combinatorial immunotherapy induces tumor-infiltrating CD8(+) T cells with distinct functional, migratory, and stem-like properties

BACKGROUND: Programmed death (ligand) 1 (PD-(L)1) blockade and OX40/4-1BB costimulation have been separately evaluated in the clinic to elicit potent antitumor T cell responses. The precise mechanisms underlying single agent activity are incompletely understood. It also remains unclear if combining...

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Detalles Bibliográficos
Autores principales: Van Braeckel-Budimir, Natalija, Dolina, Joseph Samuel, Wei, Jie, Wang, Xiao, Chen, Shih-Hsun, Santiago, Pamela, Tu, Guanghuan, Micci, Luca, Al-Khami, Amir A, Pfister, Sophia, Ram, Sripad, Sundar, Purnima, Thomas, Graham, Long, Hua, Yang, Wenjing, Potluri, Shobha, Salek-Ardakani, Shahram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672007/
https://www.ncbi.nlm.nih.gov/pubmed/34903555
http://dx.doi.org/10.1136/jitc-2021-003614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672007/
https://www.ncbi.nlm.nih.gov/pubmed/34903555
http://dx.doi.org/10.1136/jitc-2021-003614

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