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Integrated single-cell sequencing of 5-hydroxymethylcytosine and genomic DNA using scH&G-seq
The asymmetric distribution of 5-hydroxymethylcytosine (5hmC) between two DNA strands of a chromosome enables endogenous reconstruction of cellular lineages at an individual-cell-division resolution. Further, when integrated with data on genomic variants to infer clonal lineages, this combinatorial...
Autores principales: | Chialastri, Alex, Wangsanuwat, Chatarin, Dey, Siddharth S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672100/ https://www.ncbi.nlm.nih.gov/pubmed/34950891 http://dx.doi.org/10.1016/j.xpro.2021.101016 |
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