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Minimally invasive protocols and quantification for microglia-mediated perineuronal net disassembly in mouse brain

Enzymatic digestion of the extracellular matrix with chondroitinase-ABC reinstates juvenile-like plasticity in the adult cortex as it also disassembles the perineuronal nets (PNNs). The disadvantage of the enzyme is that it must be applied intracerebrally and it degrades the ECM for several weeks. H...

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Detalles Bibliográficos
Autores principales: Venturino, Alessandro, Siegert, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672101/
https://www.ncbi.nlm.nih.gov/pubmed/34950889
http://dx.doi.org/10.1016/j.xpro.2021.101012