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Minimally invasive protocols and quantification for microglia-mediated perineuronal net disassembly in mouse brain
Enzymatic digestion of the extracellular matrix with chondroitinase-ABC reinstates juvenile-like plasticity in the adult cortex as it also disassembles the perineuronal nets (PNNs). The disadvantage of the enzyme is that it must be applied intracerebrally and it degrades the ECM for several weeks. H...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672101/ https://www.ncbi.nlm.nih.gov/pubmed/34950889 http://dx.doi.org/10.1016/j.xpro.2021.101012 |