Inhibition of the Anti-Apoptotic Bcl-2 Family by BH3 Mimetics Sensitize the Mitochondrial Permeability Transition Pore Through Bax and Bak

Mitochondrial permeability transition pore (MPTP)-dependent necrosis contributes to numerous pathologies in the heart, brain, and skeletal muscle. The MPTP is a non-selective pore in the inner mitochondrial membrane that is triggered by high levels of matrix Ca(2+), and sustained opening leads to mi...

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Detalles Bibliográficos
Autores principales: Patel, Pooja, Mendoza, Arielys, Robichaux, Dexter J., Wang, Meng C., Wehrens, Xander H. T., Karch, Jason
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672142/
https://www.ncbi.nlm.nih.gov/pubmed/34926454
http://dx.doi.org/10.3389/fcell.2021.765973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672142/
https://www.ncbi.nlm.nih.gov/pubmed/34926454
http://dx.doi.org/10.3389/fcell.2021.765973

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