Lysine-specific histone demethylase 1 inhibition enhances robust fetal hemoglobin induction in human β(0)-thalassemia/hemoglobin E erythroid cells

Induction of fetal hemoglobin (HbF) ameliorates the clinical severity of β-thalassemias. Histone methyltransferase LSD1 enzyme removes methyl groups from the activating chromatin mark histone 3 lysine 4 at silenced genes, including the γ-globin genes. LSD1 inhibitor RN-1 induces HbF levels in cultur...

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Detalles Bibliográficos
Autores principales: Kaewsakulthong, Woratree, Pongpaksupasin, Phitchapa, Nualkaew, Tiwaporn, Hongeng, Suradej, Fucharoen, Suthat, Jearawiriyapaisarn, Natee, Sripichai, Orapan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672213/
https://www.ncbi.nlm.nih.gov/pubmed/35003571
http://dx.doi.org/10.4081/hr.2021.9215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672213/
https://www.ncbi.nlm.nih.gov/pubmed/35003571
http://dx.doi.org/10.4081/hr.2021.9215

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