“P(2)RY(8)-son” break of tolerance promotes SLE

In this issue of JEM, He et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20211004) associate novel P2RY8 genetic variants to lupus, expanding the field of monogenic autoimmunity. The authors demonstrate that P2RY8 prevents the expansion of DNA-reactive B cells by restraining B cell mobility a...

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Detalles Bibliográficos
Autores principales: Tusseau, Maud, Belot, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672645/
https://www.ncbi.nlm.nih.gov/pubmed/34901992
http://dx.doi.org/10.1084/jem.20211972
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author Tusseau, Maud
Belot, Alexandre
author_facet Tusseau, Maud
Belot, Alexandre
author_sort Tusseau, Maud
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description In this issue of JEM, He et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20211004) associate novel P2RY8 genetic variants to lupus, expanding the field of monogenic autoimmunity. The authors demonstrate that P2RY8 prevents the expansion of DNA-reactive B cells by restraining B cell mobility and activation within the germinal center.
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spelling pubmed-86726452022-07-03 “P(2)RY(8)-son” break of tolerance promotes SLE Tusseau, Maud Belot, Alexandre J Exp Med Insights In this issue of JEM, He et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20211004) associate novel P2RY8 genetic variants to lupus, expanding the field of monogenic autoimmunity. The authors demonstrate that P2RY8 prevents the expansion of DNA-reactive B cells by restraining B cell mobility and activation within the germinal center. Rockefeller University Press 2021-12-13 /pmc/articles/PMC8672645/ /pubmed/34901992 http://dx.doi.org/10.1084/jem.20211972 Text en © 2021 Tusseau and Belot https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
Tusseau, Maud
Belot, Alexandre
“P(2)RY(8)-son” break of tolerance promotes SLE
title “P(2)RY(8)-son” break of tolerance promotes SLE
title_full “P(2)RY(8)-son” break of tolerance promotes SLE
title_fullStr “P(2)RY(8)-son” break of tolerance promotes SLE
title_full_unstemmed “P(2)RY(8)-son” break of tolerance promotes SLE
title_short “P(2)RY(8)-son” break of tolerance promotes SLE
title_sort “p(2)ry(8)-son” break of tolerance promotes sle
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672645/
https://www.ncbi.nlm.nih.gov/pubmed/34901992
http://dx.doi.org/10.1084/jem.20211972
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