Fully synthetic Mincle-dependent self-adjuvanting cancer vaccines elicit robust humoral and T cell-dependent immune responses and protect mice from tumor development

A new strategy based on a macrophage-inducible C-type lectin (Mincle) agonist was established to construct synthetic cancer vaccines. Using sialyl-Tn (STn) as a model antigen, four conjugates with the Mincle agonist as a built-in adjuvant were designed and synthesized through a facile and efficient...

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Detalles Bibliográficos
Autores principales: Luo, Xiang, Lian, Qinghai, Li, Wenwei, Chen, Liqing, Zhang, Renyu, Yang, Deying, Gao, Lingqiang, Qi, Xiaoxiao, Liu, Zhongqiu, Liao, Guochao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672726/
https://www.ncbi.nlm.nih.gov/pubmed/35024123
http://dx.doi.org/10.1039/d1sc05736g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672726/
https://www.ncbi.nlm.nih.gov/pubmed/35024123
http://dx.doi.org/10.1039/d1sc05736g

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