Cargando…
α‐synuclein suppresses microglial autophagy and promotes neurodegeneration in a mouse model of Parkinson’s disease
The cell‐to‐cell transfer of α‐synuclein (α‐Syn) greatly contributes to Parkinson's disease (PD) pathogenesis and underlies the spread of α‐Syn pathology. During this process, extracellular α‐Syn can activate microglia and neuroinflammation, which plays an important role in PD. However, the eff...
Autores principales: | Tu, Hai‐Yue, Yuan, Bao‐Shi, Hou, Xiao‐Ou, Zhang, Xiao‐Jun, Pei, Chong‐Shuang, Ma, Ya‐Ting, Yang, Ya‐Ping, Fan, Yi, Qin, Zheng‐Hong, Liu, Chun‐Feng, Hu, Li‐Fang |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672776/ https://www.ncbi.nlm.nih.gov/pubmed/34811872 http://dx.doi.org/10.1111/acel.13522 |
Ejemplares similares
-
Regulation of α-synuclein homeostasis and inflammasome activation by microglial autophagy
por: Choi, Insup, et al.
Publicado: (2022) -
Phosphorylation of Tau and α-Synuclein Induced Neurodegeneration in MPTP Mouse Model of Parkinson’s Disease
por: Hu, Shanshan, et al.
Publicado: (2020) -
Suppression of astrocytic autophagy by αB-crystallin contributes to α-synuclein inclusion formation
por: Lu, Shen-zhao, et al.
Publicado: (2019) -
Microglial Activation and Antioxidant Responses Induced by the Parkinson’s Disease Protein α-Synuclein
por: Béraud, Dawn, et al.
Publicado: (2012) -
Catecholamines and Neurodegeneration in Parkinson’s Disease—From Diagnostic Marker to Aggregations of α-Synuclein
por: Sawada, Hideyuki, et al.
Publicado: (2013)