Cargando…
miR‐125a‐5p increases cellular DNA damage of aging males and perturbs stage‐specific embryo development via Rbm38‐p53 signaling
An increasing number of men are fathering children at an older age than in the past. While advanced maternal age has long been recognized as a risk factor for adverse reproductive outcomes, the influence of paternal age on reproduction is incompletely comprehended. Herein, we found that miR‐125a‐5p...
Autores principales: | Liang, Kuan, Yao, Liangyu, Wang, Shuxian, Zheng, Lu, Qian, Zhang, Ge, Yifeng, Chen, Li, Cheng, Xi, Ma, Rujun, Li, Chuwei, Jing, Jun, Yang, Yang, Yu, Wanwan, Xue, Tongmin, Chen, Qiwei, Cao, Siyuan, Ma, Jinzhao, Yao, Bing |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672779/ https://www.ncbi.nlm.nih.gov/pubmed/34751998 http://dx.doi.org/10.1111/acel.13508 |
Ejemplares similares
-
Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells
por: Jing, Jun, et al.
Publicado: (2020) -
Mitochondria-related miR-574 reduces sperm ATP by targeting ND5 in aging males
por: Ma, Jinzhao, et al.
Publicado: (2020) -
PPM1D phosphatase, a target of p53 and RBM38 RNA-binding protein, inhibits p53 mRNA translation via dephosphorylation of RBM38
por: Zhang, Min, et al.
Publicado: (2015) -
The Rbm38-p63 Feedback Loop Is Critical for Tumor Suppression and Longevity
por: Jiang, Yuqian, et al.
Publicado: (2018) -
Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity
por: Léveillé, Nicolas, et al.
Publicado: (2011)