Induction of somatopause in adult mice compromises bone morphology and exacerbates bone loss during aging

Somatopause refers to the gradual declines in growth hormone (GH) and insulin‐like growth factor‐1 throughout aging. To define how induced somatopause affects skeletal integrity, we used an inducible GH receptor knockout (iGHRKO) mouse model. Somatopause, induced globally at 6 months of age, resulte...

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Detalles Bibliográficos
Autores principales: Dixit, Manisha, Duran‐Ortiz, Silvana, Yildirim, Godze, Poudel, Sher Bahadur, Louis, Leeann D., Bartke, Andrzej, Schaffler, Mitchell B., Kopchick, John J., Yakar, Shoshana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672783/
https://www.ncbi.nlm.nih.gov/pubmed/34811875
http://dx.doi.org/10.1111/acel.13505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672783/
https://www.ncbi.nlm.nih.gov/pubmed/34811875
http://dx.doi.org/10.1111/acel.13505

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