Growth hormone receptor gene disruption in mature‐adult mice improves male insulin sensitivity and extends female lifespan

Studies in multiple species indicate that reducing growth hormone (GH) action enhances healthy lifespan. In fact, GH receptor knockout (GHRKO) mice hold the Methuselah prize for the world's longest‐lived laboratory mouse. We previously demonstrated that GHR ablation starting at puberty (1.5 mon...

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Detalles Bibliográficos
Autores principales: Duran‐Ortiz, Silvana, List, Edward O., Ikeno, Yuji, Young, Jonathan, Basu, Reetobrata, Bell, Stephen, McHugh, Todd, Funk, Kevin, Mathes, Samuel, Qian, Yanrong, Kulkarni, Prateek, Yakar, Shoshana, Berryman, Darlene E., Kopchick, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672790/
https://www.ncbi.nlm.nih.gov/pubmed/34811874
http://dx.doi.org/10.1111/acel.13506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672790/
https://www.ncbi.nlm.nih.gov/pubmed/34811874
http://dx.doi.org/10.1111/acel.13506

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