Cargando…
Selective oxidative stress induces dual damage to telomeres and mitochondria in human T cells
Oxidative stress caused by excess reactive oxygen species (ROS) accelerates telomere erosion and mitochondrial injury, leading to impaired cellular functions and cell death. Whether oxidative stress‐mediated telomere erosion induces mitochondrial injury, or vice versa, in human T cells—the major eff...
Autores principales: | Wang, Ling, Lu, Zeyuan, Zhao, Juan, Schank, Madison, Cao, Dechao, Dang, Xindi, Nguyen, Lam Nhat, Nguyen, Lam Ngoc Thao, Khanal, Sushant, Zhang, Jinyu, Wu, Xiao Y., El Gazzar, Mohamed, Ning, Shunbin, Moorman, Jonathan P., Yao, Zhi Q. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672791/ https://www.ncbi.nlm.nih.gov/pubmed/34752684 http://dx.doi.org/10.1111/acel.13513 |
Ejemplares similares
-
Topological DNA damage, telomere attrition and T cell senescence during chronic viral infections
por: Ji, Yingjie, et al.
Publicado: (2019) -
Telomeric injury by KML001 in human T cells induces mitochondrial dysfunction through the p53-PGC-1α pathway
por: Schank, Madison, et al.
Publicado: (2020) -
Inhibition of topoisomerase IIA (Top2α) induces telomeric DNA damage and T cell dysfunction during chronic viral infection
por: Dang, Xindi, et al.
Publicado: (2020) -
ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy
por: Zhao, Juan, et al.
Publicado: (2019) -
Mitochondrial topoisomerase 1 inhibition induces topological DNA damage and T cell dysfunction in patients with chronic viral infection
por: Dang, Xindi, et al.
Publicado: (2022)